Src family kinases in tumor progression and metastasis

摘要: The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants kinases, including the viral oncoproteins v-Src v-Yes, are capable inducing malignant transformation types. most notably although not exclusively c-Src, frequently overexpressed and/or aberrantly epithelial non-epithelial cancers. Activation is very common colorectal breast cancers, somewhat less frequent melanomas, ovarian cancer, gastric head neck pancreatic lung brain blood Further, extent increased activity often correlates with potential patient human cancers may occur through mechanisms event tumor progression. Exactly how contribute to individual tumors remains be defined completely, however they appear important for multiple aspects progression, proliferation, disruption cell/cell contacts, migration, invasiveness, resistance apoptosis, angiogenesis. This review details evidence activation tumors, emphasizes possible consequences Given ability its members participate so many progression metastasis, attractive targets future anti-cancer therapeutics.