Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic

摘要: Src is a non-receptor protein tyrosine kinase that affects proliferation, angiogenesis, differentiation, migration, invasion, and regulation of apoptosis in colorectal cancer cells. activation frequent early epigenetic event cancer, progressively increased metastatic tumors as compared with primary tumors. has also been implicated component epidermal growth factor receptor (EGFR) signal transduction. In particular, Src, mediator transactivation, can uniquely activate EGFR the absence ligand, inhibitor synergistic an monoclonal antibody vitro eliciting inhibition. inhibition vivo platinum chemotherapeutics, further increasing potential combination regimens inhibitors. The current inhibitors clinical trials are reviewed.