The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy
作者： Christopher Lieu , Scott Kopetz
关键词:
摘要: Aberrant activation of the Src family tyrosine kinases has been implicated in development and progression colorectal cancer (CRC). As a result, inhibitors are now being studied as possible therapeutic agents to treat metastatic disease. In this review, we discuss effects aberrant CRC, target single-agent drug therapy, combination therapy with epidermal growth factor receptor inhibition cytotoxic chemotherapy. The greatest potential for clinically relevant benefit most likely lies regimens. Further evaluation biomarkers will continue define molecular phenotype patients CRC who from Src-based therapy.
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