A historical perspective of the EGF receptor and related systems.
作者： Francis Edwin , Gregory J. Wiepz , Rakesh Singh , Chimera Rene Peet , Deepti Chaturvedi
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摘要: Since the isolation of epidermal growth factor (EGF) from mouse submaxillary glands in early 1950s by Cohen and coworkers, this has been shown to have various effects on numerous cellular systems. The biological physiological role that EGF plays during development adult animals led identification its receptor (EGFR) as well other members family factors their receptors. In chapter we provide a historical overview discovery EGF, family, studies actions structural characterization receptor. Further, reviewed transactivation EGFR agonists for G protein-coupled receptors (GPCRs) extracellular stimuli unrelated EGF-like ligands. Finally, an diseases, including different forms cancer, is provided.
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