Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts

作者: Michael B. Hovater , Dragos Olteanu , Elisabeth A. Welty , Erik M. Schwiebert

DOI: 10.1007/S11302-008-9102-6

关键词:

摘要: The nephron is the functional unit of kidney. Blood and plasma are continually filtered within glomeruli that begin each nephron. Adenosine 5′ triphosphate (ATP) its metabolites freely by glomerulus enter lumen beginning at proximal convoluted tubule (PCT). Flow rate, osmolality, other mechanical or chemical stimuli for ATP secretion present in segment. These ATP-release also different segment due to water salt permeability impermeability along luminal membranes cells line Each above can trigger additional release into a nephron-lining epithelial cell potential source secreted ATP. Together with derived from glomerulus, adenosine likely principal two several nucleotide nucleoside candidates renal autocrine paracrine ligands tubular fluid This minireview discusses first principles purinergic signaling as they relate urinary bladder. review how presents an ideal microenvironment. illustrates remodeled encapsulated cysts autosomal dominant polycystic kidney disease (ADPKD) pseudocysts recessive PKD (ARPKD) collecting duct create even more microenvironment signaling. Once trapped these closed microenvironments, becomes chronic plays significant epigenetic detrimental role secondary progression PKD, once remodeling tissue has begun. In cystic we argue normal provides acceleration ADPKD complete.

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