The molecular rationale of Src inhibition in colorectal carcinomas

摘要: Src has been one of the most studied proto-oncogenes. The cellular (c-Src) holds a critical role in several human malignancies and emerged as key factor that promotes tumor progression during multistep process colorectal cancer (CRC) pathogenesis. robust activation CRC aggressive phenotype poor prognosis seems to be subsequent event strong link between its deregulated activity tumor's cell adhesion properties, invasiveness metastatic potential. rarely detected genetic defects drive interest signaling networks control kinase integrate association with receptor tyrosine kinases (RTKs), such epidermal growth (EGFR). Therefore, dynamic crosstalk is being formed oncogenic capacity therapeutic applications, because inhibition sensitize previously unresponsive cells chemotherapy anti-EGFR inhibitors. present review explores molecular basis behind carcinomas. Furthermore, preclinical studies clinical trials inhibitors combination regimens are discussed, providing new insights for further investigation strategies.