Diaryl macrocycles as modulators of protein kinases
作者： Evan W. Rogers , Jingrong Jean Cui , Dayong Zhai , Yishan Li
DOI:
关键词:
摘要: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using including for treating cancer, pain, neurological diseases, autoimmune inflammation.
lens.org 参考文章(85)
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna, Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi, Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti, Alessio Amatu, Marcello Gambacorta, Luis A. Diaz, Mark Sausen, Victor E. Velculescu, Paolo Comoglio, Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, Salvatore Siena, Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer Cancer Discovery. ,vol. 3, pp. 658- 673 ,(2013) , 10.1158/2159-8290.CD-12-0558
A M Dulak, C T Gubish, L P Stabile, C Henry, J M Siegfried, HGF-independent Potentiation of EGFR Action by c-Met Oncogene. ,vol. 30, pp. 3625- 3635 ,(2011) , 10.1038/ONC.2011.84
Gromoslaw A. Smolen, Raffaella Sordella, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Heidi Archibald, Woo J. Kim, Ross A. Okimoto, Daphne W. Bell, Dennis C. Sgroi, James G. Christensen, Jeffrey Settleman, Daniel A. Haber, Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 2316- 2321 ,(2006) , 10.1073/PNAS.0508776103
Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart, A small molecule–kinase interaction map for clinical kinase inhibitors Nature Biotechnology. ,vol. 23, pp. 329- 336 ,(2005) , 10.1038/NBT1068
Elena Ghiso, Silvia Giordano, Targeting MET: why, where and how? Current Opinion in Pharmacology. ,vol. 13, pp. 511- 518 ,(2013) , 10.1016/J.COPH.2013.05.018
Daniel G Hackam, Donald A Redelmeier, None, Translation of research evidence from animals to humans. JAMA. ,vol. 296, pp. 1731- 1732 ,(2006) , 10.1001/JAMA.296.14.1731
Vinod Ravi, Wei-Lien Wang, Valerae O Lewis, Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Current Opinion in Oncology. ,vol. 23, pp. 361- 366 ,(2011) , 10.1097/CCO.0B013E328347E1E3
Ravid Straussman, Teppei Morikawa, Kevin Shee, Michal Barzily-Rokni, Zhi Rong Qian, Jinyan Du, Ashli Davis, Margaret M Mongare, Joshua Gould, Dennie T Frederick, Zachary A Cooper, Paul B Chapman, David B Solit, Antoni Ribas, Roger S Lo, Keith T Flaherty, Shuji Ogino, Jennifer A Wargo, Todd R Golub, None, Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion Nature. ,vol. 487, pp. 500- 504 ,(2012) , 10.1038/NATURE11183
Colin S. Cooper, Morag Park, Donald G. Blair, Michael A. Tainsky, Kay Huebner, Carlo M. Croce, George F. Vande Woude, Molecular cloning of a new transforming gene from a chemically transformed human cell line Nature. ,vol. 311, pp. 29- 33 ,(1984) , 10.1038/311029A0
Clive McCarthy, Edward Walker, Tropomyosin receptor kinase inhibitors: a patent update 2009 – 2013 Expert Opinion on Therapeutic Patents. ,vol. 24, pp. 731- 744 ,(2014) , 10.1517/13543776.2014.910195