Nonreceptor Tyrosine Kinases and Their Roles in Cancer

作者: Jon R. Wiener , Gary E. Gallick

DOI: 10.1007/978-1-4614-1216-8_4

关键词:

摘要: From studies on tumor development in animals to identification of the first oncogene, Src family nonreceptor tyrosine kinases has been a focus intense biological and medical interest for over 100 years. Aberrant signaling through its eight related found be common event range human cancers, increasing attention is being paid inhibition these targeted therapy cancer.

参考文章(66)
M Koegl, P Zlatkine, S C Ley, S A Courtneidge, A I Magee, Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif Biochemical Journal. ,vol. 303, pp. 749- 753 ,(1994) , 10.1042/BJ3030749
D R Stover, J Liebetanz, N B Lydon, Cdc2-mediated modulation of pp60c-src activity. Journal of Biological Chemistry. ,vol. 269, pp. 26885- 26889 ,(1994) , 10.1016/S0021-9258(18)47102-5
Heike Allgayer, Douglas D. Boyd, Markus M. Heiss, Eddie K. Abdalla, Steven A. Curley, Gary E. Gallick, Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. ,vol. 94, pp. 344- 351 ,(2002) , 10.1002/CNCR.10221
Justin M. Summy, Src family kinases in tumor progression and metastasis Cancer and Metastasis Reviews. ,vol. 22, pp. 337- 358 ,(2003) , 10.1023/A:1023772912750
Rosalyn B. Irby, Weiguang Mao, Domenico Coppola, Jimmy Kang, Jean Marc Loubeau, Walter Trudeau, Richard Karl, Donald J. Fujita, Richard Jove, Timothy J. Yeatman, Activating SRC mutation in a subset of advanced human colon cancers Nature Genetics. ,vol. 21, pp. 187- 190 ,(1999) , 10.1038/5971
Gary E. Gallick, Noel M. Han, Steven A. Curley, Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. Clinical Cancer Research. ,vol. 2, pp. 1397- 1404 ,(1996)
David R. Stover, Pascal Furet, Nicholas B. Lydon, Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain. Journal of Biological Chemistry. ,vol. 271, pp. 12481- 12487 ,(1996) , 10.1074/JBC.271.21.12481