Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway.

摘要: // Qian-Qian Zhang 1,* , Da-lei Zhou Yan Lei 1 Li Zheng Sheng-Xia Chen Hong-Ju Gou 3 Qu-Liang Gu Xiao-Dong He Tian Lan Cui-Ling Qi Jiang-Chao Yan-Qing Ding Liang Qiao 2 and Li-Jing Wang Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China Storr Liver Center, Westmead Millennium Institute for Medical Research, The Western Clinical School of the Faculty Medicine, University Sydney at Hospital, Westmead, NSW 2145, Australia Department Pathology, Nanfang Southern * These authors contributed equally to this work Correspondence: Wang, email: Qiao, Keywords : Slit2/Robo1 signaling, intestinal tumors, Src, E-cadherin, Wnt/β-catenin Received June 30, 2014 Accepted December 12, Published 18, Abstract Slit2 is often overexpressed in cancers. a secreted protein that binds Roundabout (Robo) receptors regulate cell growth migration. Here, we employed several complementary mouse models cancers, including transgenic mice, Apc Min/+ spontaneous adenoma model, DMH/DSS-induced colorectal carcinoma model clarify function signaling tumorigenesis. We showed Robo1 are tumors may contribute tumor generation. can induce precancerous lesions intestine progression. Ectopic expression activated promoted tumorigenesis growth. This was mediated part through activation Src which then down-regulated thereby activating signaling. Thus, oncogenic