Convergance of Cytoskeletal Signaling at p21-Activated Kinases
作者： Anupama E. Gururaj , Rakesh Kumar
DOI: 10.1007/978-1-4020-8341-9_5
关键词:
摘要: The PAK family of kinases regulates many aspects cellular responses to external stimuli including cell migration. This process depends on organization the actin cytoskeleton into adhesive and protrusive organelles in response extracellular signals. PAKs are important nodes for spatiotemporal control actin-based motility higher eukaryotes. also central elements sig- naling pathways that provide influence over virtually every major function, survival, differentiation proliferation. review de- picts roles migration discusses how integrate with other sub-cellular systems involved motility. Importantly, we present an overview diverse functions normal pathological contexts. Our concludes a discussion lacunae future directions field biology.
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