Activation Of The Src Family Of Tyrosine Kinases In Mammary Tumorigenesis
作者： Senthil K. Muthuswamy , William J. Muller
DOI: 10.1016/S0065-230X(08)60836-2
关键词:
摘要: Publisher Summary This chapter concentrates on the recent work that implicates activation of Src family kinases as an important event in mammary tumorigenesis. It discusses elevation c-Src kinase activity primary tumors and tumor-derived cell lines. Transgenic Mouse Models for testing role Family Mammary Tumorigenesis has been provided. The functional correlation between ligand stimulation not shown Neu receptor tyrosine (RTK), it demonstrated murine or human epithelial cells expressing a kinase-active form possess elevated pp60 c-src activity. Overexpression results loss characteristics lactogenic hormoneinduced terminal differentiation. Evidence supporting involvement tumorigenesis derives from observations made with transgenic mice PymT oncogene. establishment mouse models various epidermal growth factor (EGFR) members epithelium provides unique system which to test Studies both their derived lines levels EGFR suggest is downstream effector these kinases.
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