Tensile force on human macrophage cells promotes osteoclastogenesis through receptor activator of nuclear factor κB ligand induction

作者: Chia-Tze Kao , Tsui-Hsien Huang , Hsin-Yuan Fang , Yi-Wen Chen , Chien-Fang Chien

DOI: 10.1007/S00774-015-0690-2

关键词:

摘要: Little is known about the effects of tensile forces on osteoclastogenesis by human monocytes in absence mechanosensitive cells, including osteoblasts and fibroblasts. In this study we consider ten - sile force monocytes. The cells were treated with receptor activator nuclear fac- tor κB ligand (RANKL) to promote osteoclastogenesis. Then,expression secretion cathepsin K exam- ined. RANKL formation osteoclasts during osteoclast differentiation process under continual stress evaluated Western blot. It was also found that −100 kPa or lower induces RANKL-enhanced tar- trate-resistant acid phosphatase activity a dose-depend- ent manner. Furthermore, an increased raises expression elevated RANKL, concurrent increase TNF-recep- tor-associated factor 6 induction acti- vation. Overall, current report demonstrates ten- reinforces RANKL-induced

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