The ARS309 chromosomal replicator of Saccharomyces cerevisiae depends on an exceptional ARS consensus sequence
作者： J. F. Theis , C. S. Newlon
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摘要: Autonomously replicating sequence (ARS) elements, which function as the cis-acting chromosomal replicators in yeast Saccharomyces cerevisiae, depend upon an essential copy of 11-bp ARS consensus (ACS) for activity. Analysis chromosome III replicator ARS309 unexpectedly revealed that its ACS differs from canonical at two positions. One changes observed inactivates other elements. This atypical binds origin recognition complex efficiently and is required replication Comparison with regions elements expanded 17-bp conserved predicts core
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