Prolactin influences proliferation and apoptosis of a human IgE secreting myeloma cell line, U266.

摘要: In certain types of solid tumours and lymphomas prolactin (PRL) potentiates tumour cell proliferation exerts anti-apoptotic effect. Tumour cells themselves can produce PRL express PRL-receptors. Hyperprolactinemia is associated with different tumours, also. Multiple myeloma (MM) a haematological malignancy caused by the clonal expansion terminally differentiated plasma in bone marrow. Recently, we demonstrated immunostaining marrow MM patients an elevated level serum advanced disease. present study, tested effect on U266 human line constitutive melphalan-stimulated intracytoplasmic cells. Exogeneous inhibited immunoglobulin (Ig) production Concerning etoposide-induced apoptosis, had double-faceted depending applied dose: high, pharmacological doses (corresponding to hyperprolactinemia), whereas near physiological exerted pro-apoptotic These data indicate definite line. We direct inhibition growth, while its reciprocal apoptosis refers important regulatory role PRL.