Oligodendroglioma cells synthesize the differentiation-specific linker histone H1˚ and release it into the extracellular environment through shed vesicles.

摘要: Chromatin remodelling can be involved in some of the epigenetic modifications found tumor cells. One mechanisms at basis chromatin dynamics is likely to synthesis and incorporation replacement histone variants, such as H1˚ linker histone. Regulation expression this protein thus critical tumorigenesis. In developing brain, mainly regulated post-transcriptional level RNA-binding proteins (RBPs) are involved. past, attention focused on whole brain or isolated neurons little information available other Even less known relating glial study we report that, like maturing neurons, sharply increases differentiating astrocytes growing a serum-free medium, while corresponding mRNA decreases. Unexpectedly, cells both RNA highly expressed, spite fact that considered differentiation-specific variant. Persistence oligodendroglioma accompanied by high levels activities which seem present, least part, also actively proliferating, but not differentiating, astrocytes. Finally, cells, astrocytes, release into culture medium shedding extracellular vesicles. These findings suggest deregulation linked