Simultaneous determination of pharmaceutical components in dietary supplements for weight loss by capillary electrophoresis tandem mass spectrometry

摘要: A simple capillary electrophoresis tandem mass spectrometry method was developed for the simultaneous determination of 20 pharmaceutical components such as cathartics and appetite suppressants in dietary supplements weight loss. This allowed multidrug target screening confirmation differing radically chemical structure. The separation achieved on an uncoated fused-silica using mM ammonium formate % v/v acetonitrile-water (pH 8.0) electrolyte, followed by detection mixed with a sheath liquid that consisted mixture 5 0.1 formic acid 50 methanol-water. Samples were hydrodynamically injected separated at 30 kV within 25 min. limits 1.0-750 µg/g analytes. successfully applied to 12 loss 3 non-prescription drugs. proposed suitable identification