Independent regulation of myeloid cell growth and differentiation inducing proteins: In vivo regulation by compounds that induce inflammation

作者: Joseph Lotem , Leo Sachs

DOI: 10.1002/IJC.2910350115

关键词:

摘要: Regulation of the in vivo production myeloid cell growth-inducing (MGI-1) and differentiation-inducing (MGI-2) proteins has been studied mice injected with inflammation-inducing compounds sodium caseinate, thioglycollate bacterial lipopolysaccharide. The results indicate that these can induce MGI-1 MGI-2; different inducing agents cause a body-distribution there is an independent regulation distribution granulocyte protein (MGI-IG = G-CSF) not identical to (MGI-2). Resident peritoneal macrophages produce MGI-2 vitro, but inflammatory show reduced ability spontaneously after injection caseinate or thioglycollate. thus also macrophage activation affect regulatory MGI-2.

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