Release of Superoxide Anion by Macrophages: Effect of in Vivo or in Vitro Priming

摘要: Current definitions of cell-mediated immunity to infection include the concept that sensitized T lymphocytes respond contact with micro-organisms by releasing lymphokines, which activate macrophages enhanced microbial killing, especially intra-cellular parasites (Mackaness 1970). In vitro demonstrations from animals infected intracellular pathogens can, in fact, kill more readily have not always been conclusive, depending upon target organism used and whether or antibiotics were present reaction mixture. More recent studies, protozoa, convincing (see, e.g., Nogueira & Cohn 1978; Mauel et al. included references).