Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer.

摘要: Summary Matrix metalloproteinases (MMP) including MMP-2 and MMP-9 play a major role in tumour invasion by proteolysing the extracellular matrix. Their activation, particularly that of MMP-9, is partly dependent on plasmin inhibited TFPI-2 (tissue factor pathway inhibitor-2), serine protease inhibitor whose gene expression decreased about one-third non-small cell lung cancers (NSCLC). In addition, are essential development NSCLC can be regulated functional promoter polymorphisms. this study, −1306C/T MMP-2, −735C/T −1562C/T polymorphisms were analysed 90 patients controls. region was screened for sequence variations both groups DHPLC. A −167G/A polymorphism identified 3% controls whereas none exhibited genetic variation region. Moreover, no difference genotypes found between cases However, homozygous −1562CC genotype more frequent with squamous carcinoma than ( p =0.018). When distributions compared to tumours, relationship −1306 −1562 contrast, lower −735CC those CT or TT genotypes. survival time longer −735T allele CC =0.02). The relative risk death increased 2.6-fold =0.045; 95% CI=1.0–6.7). results study suggest might an independent prognostic marker NSCLC, but should confirmed larger cohort patients.