Update analysis of studies on the MMP-9 −1562 C>T polymorphism and cancer risk

摘要: Polymorphisms in the matrix metalloproteinase (MMP) gene have been hypothesized to be functional and may contribute genetic susceptibility cancers. The common sequence variation MMP-9 −1562 C>T (rs3918242), has involved cancer risk. However, results of related published studies were somewhat controversial underpowered general. To clarify role genotype global cancer, we performed a meta-analysis all available involving 4,124 patients 4,728 control subjects. overall indicated that there was no major association variant on stratified analysis by type showed polymorphism lower risk colorectal (OR = 0.80, 95%CI = 0.66–0.96, P heterogeneity = 0.391) lung (OR = 0.70, 95%CI = 0.51–0.96, heterogeneity = 0.959) allelic contrast. Furthermore, also observed hospital-based under dominant model (OR = 0.87, 95%CI = 0.78–0.97, heterogeneity = 0.355), contrast (OR = 0.85, 95%CI = 0.75–0.96, heterogeneity = 0.271) heterozygote comparison (OR = 0.89, 95%CI = 0.79–0.99, heterogeneity = 0.402). This pooled evidence decrease both Further prospective with larger numbers participants worldwide are required evaluate more detail.