LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma.
作者： Xin Chen , Yang Gao , Deheng Li , Yiqun Cao , Bin Hao
DOI: 10.1002/JCB.26175
关键词:
摘要: Gliomas are the most common brain tumors of center nervous system. And long non-coding RNAs (lncRNAs) non-protein coding transcripts, which have been considered as one type gene expression regulator for cancer development. In this study, we investigated role lncRNA-TP53TG1 in response to glucose deprivation human gliomas. The levels TP53TG1 glioma tissues and cells were analyzed by qRT-PCR. addition, influence on metabolism related genes at mRNA level during both high low treatment was detected MTT, clonogenicity assays, flow cytometry performed detect cell proliferation apoptosis. Furthermore, migration examined Transwell assays. significantly higher or lines compared with normal tissue NHA. Moreover, some tumor genes, such GRP78, LDHA, IDH1 up-regulated U87 LN18 under deprivation. knockdown decreased down-regulated GRP78 PKM2 However, over-expression showed opposite tendency. effects more remarkable than that glucose. Our data may promote influencing glioma. J. Cell. Biochem. 118: 4897-4904, 2017. © 2017 Wiley Periodicals, Inc.
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