Sarcopenia of aging and its metabolic impact.

摘要: Sarcopenia contributes significantly to the morbidity, decrease in quality of life, and health care costs elderly. It is characterized by a muscle mass strength, starting as early fourth decade life humans. Distinct changes include type 2 fibers myosin heavy chains IIa IIx mRNA levels. In addition, whole body protein turnover, mixed synthesis, chain mitochondrial synthesis have been reported. Different tissues organs display different responses aging, with more oxidative tissue generally having age-related changes. Exercise has shown increase aerobic capacity, well enzyme activity both young older people; however, exercise does not reverse all The metabolic effects sarcopenia resting rate secondary decreased fat-free physical activity, leading higher prevalence insulin resistance, diabetes mellitus, dyslipidemia, hypertension. way which hormone levels affect remains be fully understood. effect replacing those hormones on led some conflicting results, but further investigations are ongoing.