One step N-glycosylation by filamentous fungi biofilm in bioreactor of a new phosphodiesterase-3 inhibitor tetrazole.
作者： Paula L. de Melo Souza , Evilanna L. Arruda , Francine Pazini , Ricardo Menegatti , Boniek G. Vaz
DOI: 10.1016/J.BMCL.2016.04.085
关键词:
摘要: An efficient and rapid process for N-glycosylation of 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole-LQFM 021 (1), a new synthetic derivative pyrazole with phosphodiesterase-3 (PDE-3) inhibitory action, vasorelaxant activity low toxicity catalyzed by filamentous fungi biofilm in bioreactor was successfully developed. A maximum N-glycosyl yield 68% obtained Cunninghamella echinulata ATCC 9244 conditions 25mgml(-1) 1 PDSM medium at 28°C 96h. After extraction ethyl acetate, the identified Ultrahigh Resolution Mass Spectrometry (1)H-(13)C HSQC/HMBC.
sci-hub.se 参考文章(24)
Li-Min Duan, Hong-Ying Yu, Yan-Long Li, Chun-Juan Jia, Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3. Bioorganic & Medicinal Chemistry. ,vol. 23, pp. 6111- 6117 ,(2015) , 10.1016/J.BMC.2015.08.002
Ryuichiro Kondo, Hikari Yamagami, Kokki Sakai, Xylosylation of Phenolic Hydroxyl Groups of the Monomeric Lignin Model Compounds 4-Methylguaiacol and Vanillyl Alcohol by Coriolus versicolor. Applied and Environmental Microbiology. ,vol. 59, pp. 438- 441 ,(1993) , 10.1128/AEM.59.2.438-441.1993
C E Cerniglia, J P Freeman, R K Mitchum, Glucuronide and sulfate conjugation in the fungal metabolism of aromatic hydrocarbons. Applied and Environmental Microbiology. ,vol. 43, pp. 1070- 1075 ,(1982) , 10.1128/AEM.43.5.1070-1075.1982
Eufrânio N. da Silva Júnior, Maria Cecília B. V. de Souza, Antônio V. Pinto, Maria do Carmo F. R. Pinto, Christiane M. Nogueira, Vitor F. Ferreira, Rodrigo B. V. Azeredo, Complete and unambiguous assignments of 1H and 13C chemical shifts of new arylamino derivatives of ortho-naphthofuranquinones. Magnetic Resonance in Chemistry. ,vol. 46, pp. 1158- 1162 ,(2008) , 10.1002/MRC.2250
Wei Yuan, Li-Ping Zhang, Ke-Di Cheng, Ping Zhu, Quan Wang, Hui-Xia He, Hui-Xin Zhu, None, Microbial O-demethylation, hydroxylation, sulfation, and ribosylation of a xanthone derivative from Halenia elliptica. Journal of Natural Products. ,vol. 69, pp. 811- 814 ,(2006) , 10.1021/NP050472X
Xiao-Hong Sun, Feng Man, Li-Yan Pang, Gui-Hua Gao, Xiao-Qin Li, Xiu-Lan Qi, Fa-Mei Li, Fungal biotransformation of mosapride by Cunninghamella elegans Journal of Molecular Catalysis B-enzymatic. ,vol. 59, pp. 82- 89 ,(2009) , 10.1016/J.MOLCATB.2009.01.009
Guangtong Chen, Xue Yang, Xuguang Zhai, Min Yang, Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines. Biotechnology Letters. ,vol. 35, pp. 91- 95 ,(2013) , 10.1007/S10529-012-1053-X
Jessica Amadio, Eoin Casey, Cormac D. Murphy, Filamentous fungal biofilm for production of human drug metabolites Applied Microbiology and Biotechnology. ,vol. 97, pp. 5955- 5963 ,(2013) , 10.1007/S00253-013-4833-X
BONG-SIK YUN, YANGRAE CHO, IN-KYOUNG LEE, SOO-MUK CHO, TAE HO LEE, ICK-DONG YOO, Sterins A and B, new antioxidative compounds from Stereum hirsutum. The Journal of Antibiotics. ,vol. 55, pp. 208- 210 ,(2002) , 10.7164/ANTIBIOTICS.55.208
Keyla R.M.D. Lustosa, Ricardo Menegatti, Rodolpho C. Braga, Luciano M. Lião, Valéria de Oliveira, Microbial β-glycosylation of entacapone by Cunninghamella echinulata ATCC 9245 Journal of Bioscience and Bioengineering. ,vol. 113, pp. 611- 613 ,(2012) , 10.1016/J.JBIOSC.2012.01.004