Relaxin: An Emerging Therapy for Fibroproliferative Disorders
作者： Chrishan S. Samuel
DOI: 10.1007/978-3-642-22697-7_48
关键词:
摘要: Originally described for its ability to remodel the birth canal during pregnancy, hormone relaxin is emerging as a promising therapy fibroproliferative disorders of skin and other organs. Relaxin has been shown potently rapidly prevent reverse myofibroblast-mediated collagen production accumulation in several experimental models fibrosis, while also being able promote matrix-metalloproteinase-induced degradation. It primarily mediates these actions by interfering with TGF-β1 signaling (at level Smad2 phosphorylation) hence, TGF-β1-stimulated myofibroblast differentiation matrix synthesis. These combined along vasodilation, angiogenesis, wound healing highlight potential Dupuytren’s disease.
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