Effect of angiotensin II and angiotensin(1-7) on hematopoietic recovery after intravenous chemotherapy.

摘要: Abstract Purpose. Previous studies have shown that angiotensin peptides stimulate the proliferation of hematopoietic progenitors in vitro, promote survival after exposure to lethal irradiation as well accelerate recovery white blood cells (WBC), i.e., lymphocytes, monocytes and neutrophils, platelets. These changes level formed elements was thought be due increases numbers bone marrow including myeloid, erythroid megakaryocyte by action peptides. In view these findings, effect on chemotherapy assessed. Materials methods. The II (AII) angiotensin(1–7) (A1–7) WBC platelets blood, number myeloid intravenous administration chemotherapeutic drugs assessed a mouse model. Results. initial studies, subcutaneous 10 or 100 µg/kg per day AII starting either 2 days before 5-fluorouracil (5FU) accelerated (return baseline between 7 14 days). Further, consistent with previous observations, increased systemic comparability A(1–7) their subsequent studies. Daily both platelet peripheral marrow. As 5FU is not stem cell toxin, were repeated initiated cyclophosphamide. Following treatment cyclophosphamide circulating initially then decreased day 14. Conclusions. findings suggest multiple cellular lineages chemotherapy, perhaps through an increase early progenitors.