Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation.
作者： M B Taubman , B C Berk , B Nadal-Ginard , T Tsuda , S Izumo
DOI: 10.1016/S0021-9258(17)31290-5
关键词:
摘要: Abstract Vasoconstrictors such as angiotensin II (Ang II) play an important role in the pathogenesis of hypertension. These agonists may be responsible for abnormal vascular smooth muscle cell (VSMC) growth seen hypertension, either indirectly a consequence elevating blood pressure or directly result receptor-mediated effects on VSMC growth. To investigate whether Ang might initiate modulate some "early" genetic programs associated with VSMC, expression proto-oncogene c-fos was studied cultured rat aortic VSMC. rapidly induced accumulation mRNA, maximal levels occurring at approximately 30 min. Induction mRNA by concentration-dependent, response 100 nM. induction blocked its competitive inhibitor, [sarcosine 1,isoleucine 8]angiotensin II. not dependent upon II-stimulated intracellular alkalinization activation Na+/H+ exchange, but mobilization Ca2+ and protein kinase C activation. Epidermal factor, mitogen, also mechanism different from that results demonstrate vasoconstrictor hormone induces one earliest genes, c-fos, proliferative response.
sci-hub.st 参考文章(42)
A. Kishimoto, Y. Takai, T. Mori, U. Kikkawa, Y. Nishizuka, Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. Journal of Biological Chemistry. ,vol. 255, pp. 2273- 2276 ,(1980) , 10.1016/S0021-9258(19)85886-6
J P Moore, J A Todd, T R Hesketh, J C Metcalfe, c-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes Journal of Biological Chemistry. ,vol. 261, pp. 8158- 8162 ,(1986) , 10.1016/S0021-9258(19)83890-5
B.C. Berk, M.S. Aronow, T.A. Brock, E. Cragoe, M.A. Gimbrone, R.W. Alexander, Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways. Journal of Biological Chemistry. ,vol. 262, pp. 5057- 5064 ,(1987) , 10.1016/S0021-9258(18)61153-6
M S Kindy, G E Sonenshein, Regulation of oncogene expression in cultured aortic smooth muscle cells. Post-transcriptional control of c-myc mRNA. Journal of Biological Chemistry. ,vol. 261, pp. 12865- 12868 ,(1986) , 10.1016/S0021-9258(18)67172-8
P J Blackshear, D J Stumpo, J K Huang, R A Nemenoff, D H Spach, Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells. Journal of Biological Chemistry. ,vol. 262, pp. 7774- 7781 ,(1987) , 10.1016/S0021-9258(18)47635-1
P McCaffrey, W Ran, J Campisi, M R Rosner, Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. Journal of Biological Chemistry. ,vol. 262, pp. 1442- 1445 ,(1987) , 10.1016/S0021-9258(19)75654-3
T A Brock, S E Rittenhouse, C W Powers, L S Ekstein, M A Gimbrone, R W Alexander, Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells. Journal of Biological Chemistry. ,vol. 260, pp. 14158- 14162 ,(1985) , 10.1016/S0021-9258(17)38697-0
K K Griendling, S E Rittenhouse, T A Brock, L S Ekstein, M A Gimbrone, R W Alexander, Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. Journal of Biological Chemistry. ,vol. 261, pp. 5901- 5906 ,(1986) , 10.1016/S0021-9258(17)38468-5
J.I. Garrels, Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines. Journal of Biological Chemistry. ,vol. 254, pp. 7961- 7977 ,(1979) , 10.1016/S0021-9258(18)36039-3
B.C. Berk, T.A. Brock, M.A. Gimbrone, R.W. Alexander, Early agonist-mediated ionic events in cultured vascular smooth muscle cells. Calcium mobilization is associated with intracellular acidification. Journal of Biological Chemistry. ,vol. 262, pp. 5065- 5072 ,(1987) , 10.1016/S0021-9258(18)61154-8