Effect of diabetes on hormone-stimulated and basal hepatocyte calcium metabolism.
作者： REBECCA K. STUDER , LOUIS GANAS
关键词:
摘要: Abstract The effects of diabetes on basal calcium metabolism and the response to endocrine stimulation were studied in hepatocytes from acute long term diabetic rats. Hepatocyte sequestration turnover increased both chronic diabetes. Cytosolic free was significantly diabetics, but rise evoked by epinephrine, angiotensin, vasopressin, glucagon depressed. blunted phosphorylase-a activity diabetics influenced a 50–60% decrease total cell glycogen phosphorylase decreased cytosolic calcium. Insulin replacement corrected stimulated changes model. Depressed [3H]inositol trisphosphate formation epinephrine or vasopressin intracellular organelle buffering observed animals; may effect diminished Several possible causes for depressed in...
oup.com
sci-hub.se 参考文章(49)
M. Okamoto, M. F. White, R. Maron, C. R. Kahn, Autophosphorylation and kinase activity of insulin receptor in diabetic rats. American Journal of Physiology-endocrinology and Metabolism. ,vol. 251, ,(1986) , 10.1152/AJPENDO.1986.251.5.E542
J P Mauger, J Poggioli, F Guesdon, M Claret, Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells Biochemical Journal. ,vol. 221, pp. 121- 127 ,(1984) , 10.1042/BJ2210121
J C Parker, G J Barritt, J C Wadsworth, A kinetic investigation of the effects of adrenaline on 45Ca2+ exchange in isolated hepatocytes at different Ca2+ concentrations, at 20 degrees C and in the presence of inhibitors of mitochondrial Ca2+ transport. Biochemical Journal. ,vol. 216, pp. 51- 62 ,(1983) , 10.1042/BJ2160051
John R. Blinks, Patrick H. Mattingly, Brian R. Jewell, Menno van Leeuwen, Gary C. Harrer, David G. Allen, [31] Practical aspects of the use of aequorin as a calcium indicator: Assay, preparation, microinjection, and interpretation of signals Methods in Enzymology. ,vol. 57, pp. 292- 328 ,(1978) , 10.1016/0076-6879(78)57033-X
B Draznin, K Sussman, M Kao, D Lewis, N Sherman, The existence of an optimal range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes. Journal of Biological Chemistry. ,vol. 262, pp. 14385- 14388 ,(1987) , 10.1016/S0021-9258(18)47805-2
J H Exton, T M Chan, K E Steiner, P F Blackmore, Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Reciprocal change in alpha- and beta-adrenergic activation of hepatic glycogen phosphorylase and calcium mobilization in adrenalectomized rats. Journal of Biological Chemistry. ,vol. 254, pp. 2428- 2433 ,(1979) , 10.1016/S0021-9258(17)30240-5
B E Corkey, J R Williamson, T L Rich, B Matschinsky, J Duszynski, Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. Journal of Biological Chemistry. ,vol. 261, pp. 2567- 2574 ,(1986) , 10.1016/S0021-9258(17)35825-8
P F Blackmore, J H Exton, Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon: modulation by cAMP and phorbol myristate acetate Journal of Biological Chemistry. ,vol. 261, pp. 11056- 11063 ,(1986) , 10.1016/S0021-9258(18)67347-8
Willy STALMANS, Henri-Gery HERS, The stimulation of liver phosphorylase b by AMP, fluoride and sulfate. A technical note on the specific determination of the a and b forms of liver glycogen phosphorylase. FEBS Journal. ,vol. 54, pp. 341- 350 ,(1975) , 10.1111/J.1432-1033.1975.TB04144.X
R K Studer, A B Borle, Differences between male and female rats in the regulation of hepatic glycogenolysis. The relative role of calcium and cAMP in phosphorylase activation by catecholamines. Journal of Biological Chemistry. ,vol. 257, pp. 7987- 7993 ,(1982) , 10.1016/S0021-9258(18)34286-8