Subfertility and Risk of Testicular Cancer in the EPSAM Case-Control Study

摘要: Background/objectives It has been suggested that subfertility and testicular cancer share genetic environmental risk factors. We studied both the strongest known susceptibility gene, c-KIT ligand (KITLG), whose pathway is involved in spermatogenesis. Methods The EPSAM case-control study comprised of patients from Province Turin, Italy, diagnosed between 1997 2008. The present analysis included 245 cases 436 controls EPSAM, who were aged 20 years or older at diagnosis/recruitment. questionnaire collected information on factors such as number children, age first attempt to conceive, duration use assisted reproduction techniques, physician-assigned diagnosis infertility, siblings, self-reported cryptorchidism. Genotyping KITLG single nucleotide polymorphism (SNP) rs995030 was performed saliva samples 202 329 controls. Results Testicular associated with children fathered 5 before (odds ratio (OR) per additional child: 0.78, 95% confidence interval (CI): 0.58–1.04) sibship size (OR sibling: 0.76, CI: 0.66–0.88). When considering reproductive history until 1 year diagnosis, attempting conceive for least 12 months fathering a child using techniques not cancer, nor infertility. SNP strongly (per allele OR: 1.83; 95%CI: 1.26–2.64), but it did modify association cancer. Conclusion This supports repeatedly reported inverse does find evidence an other indicators subfertility.