Cancer stem cells and exosome signaling.

摘要: Exosomes have been recognized as mediators of intercellular communication among different cell populations in various biological model systems. By transfer signaling molecules such proteins, lipids, and RNAs between types, exosomes are implicated both physiological pathological processes. The tumor microenvironment consists multiple types cells including adult stem cells, cancer stromal cells. These known to intercommunicate with each other thereby modulating progression. Recent studies provided evidence demonstrating that mediate the interactions within microenvironment, providing new insight into how these interact through exosome signaling. This review is focused on recent examined exosome-mediated intercommunication microenvironment. Based current literature, it seems clear secret can be transferred their surrounding Likewise, also release taken up by or leading alterations phenotype. molecular mechanisms consequences remain further elucidated. A better understanding specific will likely offer opportunities development diagnostic therapeutic strategies against cancer.