Association of Fibrinogen With Cardiovascular Risk Factors and Cardiovascular Disease in the Framingham Offspring Population
作者： Izabela Lipinska , Joseph M. Massaro , Peter F.W. Wilson , James E. Muller , Ralph B. D’Agostino
DOI: 10.1161/01.CIR.102.14.1634
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摘要: Background—Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on causal pathway certain factors to exert their effect. These associations remain incompletely characterized. Moreover, optimal assay stratification is uncertain. Methods Results—In 2632 subjects from cycle 5 Framingham Offspring Population, levels were determined a newly developed immunoprecipitation test (American Biogenetic Sciences) functional Clauss method. With method, there significant linear trends across tertiles (P<0.001) age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL triglycerides men women. The method had results (P<0.030), except men. Fibrinogen ...
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