Engineered delivery strategies for enhanced control of growth factor activities in wound healing.
作者： Yiming Niu , Qiu Li , Ya Ding , Lei Dong , Chunming Wang
DOI: 10.1016/J.ADDR.2018.06.002
关键词:
摘要: Growth factors (GFs) are versatile signalling molecules that orchestrate the dynamic, multi-stage process of wound healing. Delivery exogenous GFs to milieu mediate healing in an active, physiologically-relevant manner has shown great promise laboratories; however, inherent instability GFs, accompanied with numerous safety, efficacy and cost concerns, hindered clinical success GF delivery. In this article, we highlight key overcoming these challenges is enhance control activities throughout delivering process. We summarise recent strategies based on biomaterials matrices molecular engineering, which aim improve conditions for delivery (at 'supply' end delivery), increase stability functions extracellular matrix (in transportation target cells), as well GFs/receptor interaction cell membrane 'destination' delivery). Many investigations have led encouraging outcomes various vitro vivo regenerative models considerable translational potential.
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