Multi-institutional Validation of the CAPRA-S Score to Predict Disease Recurrence and Mortality After Radical Prostatectomy

摘要: Abstract Background The University of California, San Francisco, Cancer the Prostate Risk Assessment Postsurgical (CAPRA-S) score uses pathologic data from radical prostatectomy (RP) to predict prostate cancer recurrence and mortality. However, this clinical tool has never been validated externally. Objective To validate CAPRA-S in a large, multi-institutional, external database. Design, setting, participants Shared Equal Access Regional Hospital (SEARCH) database consists 2892 men who underwent RP 2001 2011. With median follow-up 58 mo, 2670 (92%) had complete calculate score. Intervention RP. Outcome measurements statistical analysis main outcome was biochemical recurrence. Performance detecting assessed compared with postoperative nomogram by concordance index (c-index), calibration plots, decision curve analysis. Prediction cancer-specific mortality Kaplan-Meier c-index. Results limitations mean age 62 yr (standard deviation: 6.3), 34.3% 5-yr progression-free probability for those patients 0–2, 3–5, 6–10 (defining low, intermediate, high risk) 72%, 39%, 17%, respectively. c-index 0.73 validation set, 0.72 Stephenson nomogram. Although optimistic predicting likelihood being free at 5 yr, it outperformed on both plots 0.85, caveat that number is based only 61 events. Conclusions In validation, predicted after >0.70. an effective prognostic may aid determining need adjuvant therapy.