Challenges in linking preclinical anti-microbial research strategies with clinical outcomes for device-associated infections.

摘要: Infections related to implanted medical devices have become a significant health care issue in recent decades. Increasing numbers of are use, often an aging population, and these against background increasing antibiotic-resistant bacterial populations. Progressively more antibiotic resistant infections, requiring ever refined treatment options, therefore predicted emerge with greater frequency the coming Improvements prevention, diagnosis deviceassociated infections will remain priority targets both for clinicians translational research community charged addressing challenges. Preclinical strategies, predictive ultimate clinical efficacy, should serve as control point effective translation new technologies applications. The development anti-infective requires validated preclinical testing protocol; however, reliable validation experimental antimicrobial methodologies currently suffers from variety technical limitations. These include lack agreement or standardisation protocols, general correlation between vitro vivo results implant infection models (human) results. Device-associated pose additional challenges practicing concerning treatment, which complicated by biofilms formed on device. critical facing laboratories improving device-associated focus this review.