Experimental Fusarial Hyalohyphomycosis in a Murine Model

摘要: The pathogenicity of two clinical strains Fusarium solani was studied in normal and transiently neutropenic outbred CF1 CD1 male mice. Three inocula (5 x 10(5), 1 10(6), 5 10(6) spores/animal) were tested. Groups 10 mice each injected with a single intravenous dose one inoculum. Mortality correlated the inoculum, as survival significantly shorter cfu/mouse than that received or 10(5) (P less .001). Necrotizing abscesses acute branching septate hyphae, neutrophil macrophage infiltration, hemorrhage observed. median Neutropenic did not show evidence an inflammatory cellular reaction exhibited higher numbers fungi per gram infected tissue Intact host defenses able to confine infection kidneys after initial dissemination. In contrast, disseminated persisted most organs immunosuppressed animals.