Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice.

摘要: While increasing evidence demonstrates that physical exercise promotes brain health, little is known on how the reduction of activity affects function. We investigated whether cessation wheel running alters anxiety-like and depression-like behaviors its impact adult hippocampal neurogenesis in mice. Male C57BL/6 mice (4 weeks old) were assigned to one following groups, housed until 21 old; (1) no control (noEx), a standard cage; (2) (Ex), (3) exercise-no (Ex-noEx), cage for 8 subsequently cage. Behavioral evaluations suggested Ex-noEx more anxious compared noEx mice, but differences found behavior. The number BrdU-labeled surviving cells dentate gyrus was significantly higher Ex not with noEx, indicating facilitative effects cell survival are reversible. Surprisingly, ratio differentiation BrdU-positive doublecortin-positive immature neurons lower other suggesting impairs an important component These results indicate adaptation inactivity simply return conditions present sedentary As impaired predicted increase vulnerability stress-induced mood disorders, may contribute greater risk these disorders.