Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).

作者: M. J. OBREGON , A. PASCUAL , J. MALLOL , MORREALE DE ESCOBAR , F. ESCOBAR DEL REY

DOI: 10.1210/ENDO-106-6-1827

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摘要: To determine whether T4 has an intrinsic effect at the pituitary level, it would be important to block conversion of T3 completely. We have attempted achieve this with iopanoic acid (IOP), a radiographic contrast agent. then measured in same animals effects such treatment on or deiodination and response dose T3. Plasma TSH levels GH content were as biological end points. Thyroidectomized rats injected single (1.7 μg/100 g BW) labeled [125I]T4 (Exp A) (0.33 [125I]T3 B) treated IOP solvent. Animals Exp A killed 24 h after iodothyronine injection those B 4, 12, iodothyronine. The concentrations several tissues, including anterior pituitary, extraction paper chromatography an...

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