Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease

摘要: Cognitive impairment and neuropsychiatric symptoms (NPS) are frequent in patients with Parkinson disease (PD), negatively impacting patients’ quality of life increasing caregiver burden.1 Approximately 25% non-demented PD have mild cognitive (MCI),2 up to 80% all will eventually develop dementia.3 Psychosis, depression, anxiety, apathy, impulse control disorders (ICDs) the most problematic NPS.1 To what extent NPS attributable neurodegenerative process, psychosocial, demographic or clinical factors, a complication dopamine replacement therapy (DRT) is unclear. The contribution each factor may differ by stage other variables. To better understand cognition PD, need be studied soon after diagnosis, before initiation DRT. Preliminary studies shown that significant percentage (10%–30%) new (sometimes treated) deficits at rates higher than healthy controls (HCs).4–8 Others range more common early compared HCs,8–10 non-motor predominating newly diagnosed, untreated patients.11 The Parkinson’s Progression Markers Initiative (PPMI) largest ongoing, prospective, longitudinal study (at enrollment) HCs.12 Here we report frequency correlates (CI) baseline.