Role of maternal pertussis antibodies in infants.

摘要: Pertussis remains a serious infection in young infants. Most deaths occur the first 3 months of life, before administration dose pertussis vaccine. antibodies are transferred from mother to infant; but because lack serologic correlates protection, it is difficult determine proportion infants born with protective concentration maternal antibodies. Indirect evidence suggests that provide short lived protection against fatal pertussis. It hoped could be enhanced by or neonatal vaccination. The possibility protecting immunizing their mothers during pregnancy was investigated 1930s and 1940s; no further studies have been published since. Recent animal human provided immunization acellular vaccine can efficiently prime T B cells act as basis for future immune response. limited data on promising call research reduce vulnerability disease.