The impact of the COVID-19 pandemic on cerebrovascular disease

摘要: ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a systemic disease that affects nearly all organ systems through infection and subsequent dysregulation of the vascular endothelium. One most striking phenomena has been 2019 (COVID-19)–associated coagulopathy. Given these findings, questions naturally emerged about prothrombotic impact COVID-19 on cerebrovascular whether ischemic stroke is clinical feature specific to pathophysiology. Early reports from China several sites in northeastern United States seemed confirm suspicions. Since initial reports, many cohort studies worldwide observed decreased rates since start pandemic, raising concerns for broader pandemic treatment. In this review, we provide comprehensive assessment how affected presentation, epidemiology, treatment, outcomes better understand disease. Much evidence suggests decline admissions stems global response virus, which made it more difficult patients get hospital once symptoms start. However, there does not appear be demonstrable quality metrics arrive at hospital. Despite concerns, insufficient ascribe causal relationship pathogenicity SARS-CoV-2 cerebral vasculature. Nevertheless, when infected with present stroke, their presentation likely severe, they have markedly higher rate in-hospital mortality than either or alone.