Flexible Bayesian methods for cancer phase I clinical trials. Dose escalation with overdose control
作者： Mourad Tighiouart , André Rogatko , James S. Babb
DOI: 10.1002/SIM.2106
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摘要: SUMMARY We examine a large class of prior distributions to model the dose–response relationship in cancer phase I clinical trials. parameterize dose–toxicity terms maximum tolerated dose (MTD) � and probability limiting toxicity (DLT) at initial 0. The MTD is estimated using EWOC (escalation with overdose control) method Babb et al. show through simulations that candidate joint for (� 0 ;� ) negative priori correlation structure results safer trial than
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