Novel and Efficient Translational Clinical Trial Designs in Advanced Prostate Cancer

摘要: We propose a new paradigm for the clinical evaluation of cancer therapies. It entails adjusting search optimal dose on basis measurable patient characteristics that may be predictive adverse responses to treatment, and extending this beyond phase I into phases II III. provide examples how fine-tuning involve use patient-specific attributes obtain personalized treatment regimen; novel methods design can used update working conduct III trials.