Human Cancer Immunology

摘要: Much work in cancer immunology is based on the assumption that cells can be distinguished from normal by presence of distinctive antigens their surface. The evidence supporting this comes primarily transplantation experiments inbred mice and rats with tumors induced chemical carcinogens or viruses. demonstration these are immunogenic syngeneic hosts, even host which tumor originated, represents cornerstone field immunology. Not all transplanted experimental animals immunogenic, however. In view some, nonimmunogenic raise serious questions about general validity immunosurveillance concept thus whole Others contend lack immunogenicity may related to any aspect recognition-rejection complex need not indicate absence tumor-specific antigens. This supported surprising array escape routes known antigenicity immunologic destruction.