Psychological predictors of peptic ulcer incidence in the Alameda County Study.

摘要: It has often been suggested that mood and personality predispose to peptic ulcer, but little prospective evidence exists. We used longitudinal data from the Alameda County Study seek associations of psychological characteristics with later ulcer development, taking into account possible confounding or mediating, mediating roles nonpsychological factors. Among 4,595 subjects ulcer-free in 1965, we studied five baseline measures (depression, hostility, ego resiliency, social alienation anomy, personal uncertainty) respect reported 1973-1974. All had significant age-adjusted incident [odds ratio (O.R.) 1.8-2.6]. After adjustment for smoking, drinking, skipping breakfast, lack sleep, painful medical conditions, liver disease, three remained significant: depression, hostility. The O.R. 2.8 [95% confidence interval (C.I.) 1.6, 4.8] an upper versus a lower tertile index independently predictive factors fell 2.1 health-related behaviors reached 1.7 (C.I. 1.0, 3.1) after addition education model. conclude maladjustment, hostility are prospectively associated ulcer. These partially accounted by mediation standard risk factors, some extent related socioeconomic status.