Enriched Environment Altered Aberrant Hippocampal Neurogenesis and Improved Long-Term Consequences After Temporal Lobe Epilepsy in Adult Rats.
作者： Xiaoqian Zhang , Tingting Liu , Zhike Zhou , Xiaopeng Mu , Chengguang Song
DOI: 10.1007/S12031-015-0571-0
关键词:
摘要: Abnormal hippocampal neurogenesis is thought to contribute cognitive impairments in chronic temporal lobe epilepsy (TLE). Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles neurogenesis. We investigated whether enriched environment (EE) might be beneficial for TLE. Adult rats were randomly assigned as control rats, subjected status epilepticus (SE), or post-SE treated with EE 30 days. used immunofluorescence staining analyze the Nissl evaluate damage. Electroencephalography was measure duration of spontaneous seizures. Cognitive function evaluated by Morris water maze. Western blot expression SDF-1 hippocampus. In present study, we found TLE model resulted aberrant such reduced proliferation, intensified dendritic development newborn neurons, well seizures impairments. More importantly, treatment significantly increased cell proliferation survival, extended apical dendrites, delayed attenuation CXCR4, accompanied decreased long-term seizure activity improved adult after These results provided morphological evidence that treating
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