A Prospective Evaluation of Systemic Biomarkers and Cognitive Function Associated with Carotid Revascularization.

摘要: Objective To determine factors affecting cognition and identify predictors of long-term cognitive impairment following carotid revascularization procedures. Background Cognitive is common in older patients with occlusive diseases. Methods Patients undergoing intervention for severe diseases were prospectively recruited. received neurocognitive testing before, 1, 6 months after interventions. Plasma samples also collected within 24 hours inflammatory cytokines analyzed. Univariate multivariate logistic regressions performed to risk associated significant deterioration (>10% decline). Results A total 98 (48% symptomatic) recruited, including 55 receiving stenting 43 endarterectomy. Mean age was 69 (range 54-91 years). had overall improvement measures 1 month revascularization. When compared stenting, endarterectomy demonstrated postoperative at baseline. Carotid (odds ratio 6.49, P = 0.020) greater than 80 years 12.6, 0.023) a impairment. Multiple showed changes On analysis, controlling procedure age, IL-12p40 (P 0.041) higher month; SDF1-α 0.004) tumor necrosis factor alpha 0.006) independent impairment, whereas interleukin-6 0.019) protective effects Conclusions interventions affect function. Systemic biomarkers can be used decline postprocedures that benefit from targeted training.