Dosing in Obese Critically Ill Patients
作者： Maya Hites , Fabio Silvio Taccone
DOI: 10.1007/978-981-10-5336-8_4
关键词:
摘要: As the prevalence of obesity continues to rise significantly worldwide, an increasing number overweight patients are expected present hospital with various pathological conditions. In particular, obese at risk for acquiring infections. When facing life-threatening infections in critically ill patients, careful antibiotic dose adjustment based on pharmacokinetic/pharmacodynamic (PK/PD) considerations is necessary because hospital-related often caused by pathogens decreased susceptibility (as compared community isolates) and drug handling altered this patient population. Antibiotic PK may be even further patients. chapter, we will explore why more susceptible than lean individuals, what possible changes due per se, how use principles optimize dosing strategies
ulb.ac.be
springer.com
core.ac.uk 
sci-hub.se 参考文章(150)
Patricia B. Christoff, David R. Conti, Cartha Naylor, William J. Jusko, Procainamide disposition in obesity. Annals of Pharmacotherapy. ,vol. 17, pp. 516- 522 ,(1983) , 10.1177/106002808301700704
S L Welle, G B Forbes, Lean body mass in obesity. International Journal of Obesity. ,vol. 7, pp. 99- 107 ,(1983)
Marcia Divoll, Richard I. Shader, David J. Greenblatt, Darrell R. Abernethy, Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen. Journal of Laboratory and Clinical Medicine. ,vol. 101, pp. 873- 880 ,(1983)
MN Marwyne, CY Loo, AG Halim, K Norella, T Sulaiman, MI Zaleha, None, Estimation of glomerular filtration rate using serum cystatin C in overweight and obese subjects. The Medical journal of Malaysia. ,vol. 66, pp. 313- 317 ,(2011)
Lucinda K. M. Summers, Jaswinder S. Samra, Sandy M. Humphreys, Richard J. Morris, Keith N. Frayn, Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clinical Science. ,vol. 91, pp. 679- 683 ,(1996) , 10.1042/CS0910679
Marco Rossi, Monica Nannipieri, Marco Anselmino, Daniela Guarino, Ferdinando Franzoni, Margherita Pesce, Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: long term effect of gastric bypass surgery. Clinical Hemorheology and Microcirculation. ,vol. 51, pp. 159- 167 ,(2012) , 10.3233/CH-2011-1517
Manjunath P Pai, Treatment of bacterial infections in obese adult patients: how to appropriately manage antimicrobial dosage Current Opinion in Pharmacology. ,vol. 24, pp. 12- 17 ,(2015) , 10.1016/J.COPH.2015.06.004
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. The Lancet. ,vol. 363, pp. 157- 163 ,(2004) , 10.1016/S0140-6736(03)15268-3
John M. Chapman, Frank J. Massey, The interrelationship of serum cholesterol, hypertension, body weight, and risk of coronary disease: Results of the first ten years' follow-up in the Los Angeles Heart Study Journal of Chronic Diseases. ,vol. 17, pp. 933- 949 ,(1964) , 10.1016/0021-9681(64)90163-8
Choban Ps, Burge Jc, Heckler R, Flancbaum L, Increased incidence of nosocomial infections in obese surgical patients. American Surgeon. ,vol. 61, pp. 1001- 1005 ,(1995)