Estimation of glomerular filtration rate using serum cystatin C in overweight and obese subjects.
作者： MN Marwyne , CY Loo , AG Halim , K Norella , T Sulaiman
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摘要: BACKGROUND Obesity and overweight are strong independent risk factors for chronic kidney disease (CKD). Using serum creatinine-based estimated glomerular filtration rate (eGFR) equations in these subjects may be inaccurate. On the other hand, cystatin C-based eGFR overestimate CKD prevalence as recent findings suggest an association of C with obesity. The objective this study was to assess accuracy a equation compared two creatinine -based obese subjects. METHODS This prospective cross-sectional which recruited healthy volunteers aged 18-55 years body mass index (BMI) > or = 23kg/m(2) (Asia Pacific Guidelines). Their renal profiles, 99m technetium diethylene triamine pentacetic acid (99)mTc-DTPA) scans were performed on same day. correlations (99)mTc-DTPA GFR determined. RESULTS One hundred one median age 30.0 (27.0-43.5) mean BMI 28.7 +/- 4.5 kg/m(2) recruited. showed best correlation (r 0.526, p 0.001) more accurate measuring abnormal equations. CONCLUSION Our that accurate, sensitive specific
参考文章(29)
Nawar M. Shara, Jason G. Umans, Helaine E. Resnick, Barbara V. Howard, Suma Vupputuri, Jiaqiong Xu, Li Lu, Decreased GFR estimated by MDRD or Cockcroft-Gault equation predicts incident CVD: the strong heart study. Journal of Nephrology. ,vol. 22, pp. 373- 380 ,(2009)
Linda F. Fried, Jung Sun Lee, Michael Shlipak, Glenn M. Chertow, Christie Green, Jingzhong Ding, Tamara Harris, Anne B. Newman, , Chronic kidney disease and functional limitation in older people: health, aging and body composition study. Journal of the American Geriatrics Society. ,vol. 54, pp. 750- 756 ,(2006) , 10.1111/J.1532-5415.2006.00727.X
Donald W. Cockcroft, Henry Gault, Prediction of Creatinine Clearance from Serum Creatinine Nephron. ,vol. 16, pp. 31- 41 ,(1976) , 10.1159/000180580
Arend Bökenkamp, Michael Domanetzki, Raymund Zinck, Gerhard Schumann, Dennis Byrd, Johannes Brodehl, Cystatin C Serum Concentrations Underestimate Glomerular Filtration Rate in Renal Transplant Recipients Clinical Chemistry. ,vol. 45, pp. 1866- 1868 ,(1999) , 10.1093/CLINCHEM/45.10.1866
G. Eknoyan, Adolphe Quetelet (1796–1874)—the average man and indices of obesity Nephrology Dialysis Transplantation. ,vol. 23, pp. 47- 51 ,(2007) , 10.1093/NDT/GFM517
Caroline S Fox, Martin G Larson, Eric P Leip, Bruce Culleton, Peter WF Wilson, Daniel Levy, Predictors of New-Onset Kidney Disease in a Community-Based Population JAMA. ,vol. 291, pp. 844- 850 ,(2004) , 10.1001/JAMA.291.7.844
A. Saracino, L.F. Morrone, V. Suriano, A. Niccoli-Asabella, A. Ramunni, M. Fanelli, G. Rubini, P. Coratelli, A simple method for correcting overestimated glomerular filtration rate in obese subjects evaluated by the Cockcroft and Gault formula: a comparison with 51Cr EDTA clearance. Clinical Nephrology. ,vol. 62, pp. 97- 103 ,(2004) , 10.5414/CNP62097
Soraya Taleb, Raffaella Cancello, Karine Clément, Daniele Lacasa, Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation. Endocrinology. ,vol. 147, pp. 4950- 4959 ,(2006) , 10.1210/EN.2006-0386
Nadia Naour, Soraya Fellahi, Jean-François Renucci, Christine Poitou, Christine Rouault, Arnaud Basdevant, Anne Dutour, Marie-Christine Alessi, Jean-Philippe Bastard, Karine Clément, Michèle Guerre-Millo, Potential Contribution of Adipose Tissue to Elevated Serum Cystatin C in Human Obesity Obesity. ,vol. 17, pp. 2121- 2126 ,(2009) , 10.1038/OBY.2009.96
Aviva Must, Jennifer Spadano, Eugenie H Coakley, Alison E Field, Graham Colditz, William H Dietz, The Disease Burden Associated with Overweight and Obesity JAMA. ,vol. 282, pp. 1523- 1529 ,(1999) , 10.1001/JAMA.282.16.1523