Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy

作者: Masoud Mokhtarani , Bruce Scharschmidt

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摘要: The present disclosure provides methods for treating hepatic encephalopathy (HE) and optimizing adjusting nitrogen scavenging drug dosage subjects with HE, comprising administering a at sufficient to maintain a. fasting blood ammonia level or below specified threshold which is 1.5 times the upper limit of normal ammonia. administered in method phenylacetic acid prodrug selected from HPN-100, PBA, NaPBA, sodium benzoate, any combination thereof (i.e., two more NaPBA).

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