Recognition of herpesviruses by the innate immune system

摘要: Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at cell surface and intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses replicate nucleus, initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both within endosomes cytosol. In article we describe recent advances our understanding detection translates into anti-herpesvirus host defence, seek to evade establish persistent infections.