Meloxicam Does Not Affect the Antiplatelet Effect of Aspirin in Healthy Male and Female Volunteers

作者: Joanne van Ryn , Monika Kink-Eiband , Ingrid Kuritsch , Ulrich Feifel , Gertraud Hanft

DOI: 10.1177/0091270004266623

关键词:

摘要: This study determined if meloxicam, a selective cyclooxygenase (COX)‐2 inhibitor, interferes with the antiplatelet effect of aspirin using platelet aggregation and thromboxane (Tx) B 2 …

参考文章(32)
Neal M. Davies, Clinical pharmacokinetics of ibuprofen. The first 30 years Clinical Pharmacokinectics. ,vol. 34, pp. 101- 154 ,(1998) , 10.2165/00003088-199834020-00002
A DEMEIJER, Meloxicam, 15 mg/day, spares platelet function in healthy volunteers. Clinical Pharmacology & Therapeutics. ,vol. 66, pp. 425- 430 ,(1999) , 10.1053/CP.1999.V66.A101063
G. Engelhardt, R. Bögel, Chr. Schnitzler, R. Utzmann, Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings. Biochemical Pharmacology. ,vol. 51, pp. 29- 38 ,(1996) , 10.1016/0006-2952(95)02110-8
Inge de Lepeleire, Marleen Depré, Kathleen Wynants, Anne van Hecken, Agnes Buntinx, Jef Arnout, Barry J. Gertz, David L. Ebel, Aimee Dallob, Peggy H. Wong, Jules I. Schwartz, Wesley Tanaka, Paul J. de Schepper, Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. The Journal of Clinical Pharmacology. ,vol. 40, pp. 1109- 1120 ,(2000) , 10.1177/009127000004001005
W M Parks, J C Hoak, R L Czervionke, Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. Journal of Pharmacology and Experimental Therapeutics. ,vol. 219, pp. 415- 419 ,(1981)
M. Livio, A. Del Maschio, C. Cerletti, G. de Gaetano, Indomethacin prevents the long-lasting inhibitory effect of aspirin on human platelet cyclo-oxygenase activity Prostaglandins. ,vol. 23, pp. 787- 796 ,(1982) , 10.1016/0090-6980(82)90123-X
Patricia Clutton, John D. Folts, Jane E. Freedman, Pharmacological control of platelet function. Pharmacological Research. ,vol. 44, pp. 255- 264 ,(2001) , 10.1006/PHRS.2001.0861
Frank Degner, Ralf Sigmund, Henning Zeidler, Efficacy and tolerability of meloxicam in an observational, controlled cohort study in patients with rheumatic disease. Clinical Therapeutics. ,vol. 22, pp. 400- 410 ,(2000) , 10.1016/S0149-2918(00)89009-8
Francesca Catella-Lawson, Muredach P. Reilly, Shiv C. Kapoor, Andrew J. Cucchiara, Susan DeMarco, Barbara Tournier, Sachin N. Vyas, Garret A. FitzGerald, Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin The New England Journal of Medicine. ,vol. 345, pp. 1809- 1817 ,(2001) , 10.1056/NEJMOA003199